Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor β cytokine superfamily, the protein is secreted as a 25 kDa disulfide linked dimer [1]. Circulating GDF-15 levels are associated with cancers, cardiovascular and kidney diseases [2-4]. GDF-15 regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses [5].
References:
[1] Bootcov M. R., et al. (1997) PNAS; 94:11514-11519. [2] Welsh J.B., et al. (2003) PNAS;100:3410-3415. [3] Wang T. J, et al. (2012) Circulation 126; 1596– 1604. [4] Nair V., et al. (2017) J.Am. Soc. Nephol. 28 2223-2240. [5] Hsu J-Y, et al. (2017) Nature; 550: 255-259.
Catalogue Number: 32980
Elisa: 96-well
