Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), 24p3, or neutrophil lipocalin (NL), is a 25-kDa secretory glycoprotein. LCN2 has been implicated in a variety of cellular processes including the innate immune response, infection, differentiation, tumorigenesis and cell survival. It appears to be up- regulated in various inflammation and infection conditions. Several reports suggest that LCN2 may represent a sensitive biomarker for various renal and lung injuries and is associated with several types of cancers, including breast cancer, ovarian, colorectal and pancreatic cancers. Furthermore, serum levels of LCN2 are correlated with obesity, insulin resistance, hyperglycemia, coronary heart disease and fatty liver disease in humans.
Relevant recent publications:
1. AEmerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndrome. Jang Y, Lee JH, Wang Y, Sweeney G. Clin Exp Pharmacol Physiol. 2012 Feb;39(2):194-9
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