In bone, collagen type I is synthesized by osteoblasts in the form of procollagen. This precursor contains a short signal sequence and terminal extension peptides: amino-terminal propeptide (PINP) and carboxy-terminal propeptide. These propeptide extensions are removed by specific proteinases before the collagen molecules form. Both propeptides can be found in the circulation and their concentration reflects the synthesis rate of collagen type I [1] [2] .
References:
[1] Patrick R. L., et al. (2012) Cold Spring Harb Perspect Med 2: a 00627. [2] Morikawa N., et al. (2019) Int Heart J 20;60(2):310-317.
Catalogue Number: 31109
Elisa: 96-well