The autotaxin-lysophophatidic acid (ATX-LPA) signaling pathway is implicated in a variety of human disease states including angiogenesis, autoimmune diseases, cancer, fibrotic diseases, inflammation, neurodegeneration, and neuropathic pain.
The critical role and potential target of the autotaxin/lysophosphatidate axis in pancreatic cancer.
Quan M, Cui JJ, Feng X, Huang Q.
Tumour Biol. 2017 Mar;39(3):1010428317694544.
Autotaxin-LPA receptor axis in the pathogenesis of lung diseases.
Chu X, Wei X, Lu S, He P.
Int J Clin Exp Med. 2015 Oct 15;8(10):17117-22.
Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature.
Castagna D, Budd DC, Macdonald SJ, Jamieson C, Watson AJ.
J Med Chem. 2016 Jun 23;59(12):5604-21.
