Angiopoietin-like proteins (ANGPTLs) are a group of eight proteins that share structural similarity to the members of the angiopoietin protein family. ANGPTL4, which functions as a homo-oligomer different from ANGPTL3 and ANGPTL8, not only regulates the plasma levels of triglyceride and prevents the uptake of dietary lipids into adipose tissues but also inhibits intravascular lipolysis.

Angiopoietin-like 4: A molecular link between insulin resistance and rheumatoid arthritis.

Masuko K.

J Orthop Res. 2017 May;35(5):939-943

Lipoprotein lipase and angiopoietin-like 4 – Cardiomyocyte secretory proteins that regulate metabolism during diabetic heart disease.

Puthanveetil P, Wan A, Rodrigues B.

Crit Rev Clin Lab Sci. 2015;52(3):138-49.