The adaptor proteins APPL1 and APPL2 (Adaptor protein-containing an NH2-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central Pleckstrin homology (PH) domain, Phosphotyrosine-binding (PTB) domain, and Leucine zipper motif), regulate adiponectin action and insulin-sensitivity in multiple insulin-responsive tissues.
Relevant recent publications:
1. Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin. Cheng KK, Lam KS, Wang B, Xu A. Best Pract Res Clin Endocrinol Metab. 2014 28(1):3-13
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