Interleukin-33 (IL-33) has an important role in allergic inflammation. It is a tissue-derived nuclear cytokine from the IL-1 family. IL-33 is abundantly expressed in endothelial cells, epithelial cells and fibroblast-like cells and acts as an alarm signal (alarmin) released upon cell injury or tissue damage to alert immune cells expressing the ST2 receptor (IL-1RL1).
IL-33/IL-31 Axis: A Potential Inflammatory Pathway.
Di Salvo E, Ventura-Spagnolo E, Casciaro M, Navarra M, Gangemi S.
Mediators Inflamm. 2018 Mar 11;2018:3858032.
Pathophysiology of IL-33 and IL-17 in allergic disorders.
Gupta RK, Gupta K, Dwivedi PD.
Cytokine Growth Factor Rev. 2017 Dec;38:22-36.
