Fibroblast Growth Factor 1 (FGF-1), also known as FGF acidic, ECGF, and HBGF1, is a non-glycosylated member of the FGF family of mitogenic peptides. Produced by multiple cell types, FGF1 stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It plays roles in development, regeneration, and angiogenesis. The ability of heparin sulfate to bind FGF acidic is determined by its pattern of sulfation, and alterations in this pattern during embryogenesis thereby regulate FGF acidic bioactivity. The association of FGF acidic with heparin sulfate is a prerequisite for its subsequent interaction with FGF receptors. Intracellular FGF acidic functions as a survival factor by inhibiting p53 activity and proapoptotic signaling.
Catalogue Number: 41990
