FGF2, also called FGF basic, is a member of the FGF family of at least 23 related mitogenic proteins which has been isolated from a number of sources, including neural tissue, pituitary, adrenal cortex, corpus luteum, and placenta. FGF2 stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. Besides, FGF2 induces neuron differentiation, survival, regeneration, and also modulates embryonic development and differentiation. These observed in vitro functions of FGF2 suggest FGF2 may play a role in vivo in the modulation of such normal processes as angiogenesis, wound healing and tissue repair, embryonic development and differentiation, and neuronal function and neural degeneration. Additionally, FGF basic may participate in the production of a variety of pathological conditions resulting from excessive cell proliferation and excessive angiogenesis.
Catalogue Number: 41880
