FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1. Mature human FGF23 contains an atypical (very low affinity) heparin binding site (aa 134162), a proteolytic cleavage site (Arg179Ser180), and multiple Olinked glycosylation sites with Thr178 being of particular importance. Olinked glycosylation at Thr178 blocks the cleavage of FGF23, thereby preventing loss of FGF23 activity. This recombinant human FGF23 bears mutation at 179th aa from arginine to glutamine preventing proteolytic cleavage.
Catalogue Number: 41295
