FGF21, a polypeptide with 210 amino acid residues produced mostly from the liver tissue.[1] Mouse FGF21 shares 75% identity as human FGF21. Recent animal studies indicate it possesses potent beneficial effects on glucose and lipid metabolism and insulin sensitivity.[2] Increasing data shows FGF21 can significantly stimulate glucose uptake in mature adipocytes. And The lowered LDL-cholesterol and increased HDL-cholesterol can also be observed.[2,3] FGF21 exerts its bioactivity through interaction with membrane bound FGF receptors (FGFRs) which requires β-Klotho as a co-factor to bind and activate FGFR signaling.[4,5]The activation of FGF21 can induce the stimulation of diverse downstream pathways medicated by MAPK,FRS-2, SHP-2, PI3K, raf, stat and other signaling molecules.[6-9] In sum, FGF21 induces a variety of significant beneficial metabolic changes without apparent adverse effects which makes this factor a hot candidate to treat some metabolic diseases.[10]
Catalogue Number: 41184
