• Histones are DNA-associated cationic proteins in the nucleus of eukaryotic cells to form nucleosomes. Anti-histone autoantibodies are present in a number of clinical conditions, primarily in systemic lupus erythematosus (SLE, ~80%) and drug-induced lupus (DIL, ~95%) by procainamide, hydralazine, chlorpromazine, and quinidine. Additionally, these autoantibodies are also detectable in other rheumatic diseases, including myositis and systemic sclerosis (SSc).
• Elisa kit for quantitative measurement of anti-histone autoantibodies in human blood samples, with superior reproducibility, specificity and sensitivity, ready for clinical application:

Typical results
(Example only, not for calculation of actual results)

References:

1. Dumortier, H., & Muller, S. (2007). Histone Autoantibodies. In Autoantibodies (pp. 169- 176). Elsevier.
2. Dooley, M. A. (2016). Drug-induced Lupus. In Systemic Lupus Erythematosus (pp. 473- 479). Academic Press. Firestein, G. S., Budd, R., Gabriel, S. E., Mcinnes, I. B., & O’dell, J. R. (2016). Kelley And Firestein’s Textbook Of Rheumatology E-book. Elsevier Health Sciences.
3. Portanova, J. P., Arndt, R. E., Tan, E. M., & Kotzin, B. L. (1987). Anti-histone Antibodies In Idiopathic And Drug- induced Lupus Recognize Distinct Intrahistone Regions. The Journal Of Immunology, 138(2), 446-451.
4. Portanova, J. P., Rubin, R. L., Joslin, F. G., Agnello, V. D., & Tan, E. M. (1982). Reactivity Of Anti-histone Antibodies Induced By Procainamide And Hydralazine. Clinical Immunology And Immunopathology, 25(1), 67-79.