Small nuclear ribonucleoprotein complexes (abbreviated as U-snRNP) are essential for splicing of precursor mRNA molecules. Seven different Sm proteins aggregate into a heteroheptameric protein core, including small nuclear ribonucleoprotein Sm D1 (SmD1 or snRNPD1). In the blood of patients with systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.
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