Rheumatoid Factor (RF) is an abnormal antibody made by human immune system which can bind to other healthy antibodies and destroy the function of patients’ normal immune system. High levels of rheumatoid factor in the plasma are most often related to autoimmune diseases, such as rheumatoid arthritis and Sjogren’s syndrome. Therefore, RF is a more accurate and sensitive biomarker for diagnosing autoimmune diseases. In clinical research, the increase in serum secretion of RF has not be only indicated rheumatoid arthritis and Sjogren’s syndrome, but also associated with a number of other diseases, e.g. Cancer, Chronic infections, Inflammatory lung diseases, Mixed connective tissue disease, Systemic lupus erythematosus. Thus, monitoring RF levels has a great clinic significance for general health screening, especially in older age group. The reference value of the RF in plasma is < 14 IU/ml.
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