During mRNA translation at ribosomes, specific amino-acyl-tRNA synthetases are required for the covalent attachment between tRNAs and different amino acids. Threonyl-tRNA synthetase (TARS, PL-7) is specific for the amino acid threonine.
PL-7 is recognized by PL-7 autoantibodies which is present in a subset of patients with polymyositis and dermatomyositis.
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