Phospho Akt (Ser473)

Akt, also known as PKB, is a critical component of signaling pathways stimulated by various hormones and growth factors, such as insulin. Akt plays an important role in regulating cell metabolism and apoptosis. Akt is activated by phosphorylation at Thr308 by PDK1 and by phosphorylation at Ser473 by mammalian target of rapamycin (mTOR).

Relevant  publications:
1. PI3K-PKB/Akt pathway. Hemmings BA, Restuccia DF. Cold Spring Harb Perspect Biol. 2012 4(9):a011189

2. Akt, FoxO and regulation of apoptosis. Zhang X, Tang N, Hadden TJ, Rishi AK. Biochim Biophys Acta. 2011 1813(11):1978-86

3. Akt signalling in health and disease. Hers I, Vincent EE, Tavaré JM. Cell Signal. 2011 Oct;23(10):1515-27.

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