Neutrophil elastase (NE), also known as leukocyte elastase, serine elastase, and elaszym, is one of the hematopoietic serine proteases localized in the primary granules of polymorphonuclear neutrophils (PMNs)1. The primary function of NE is recognized as to participate in the clearance of invaded pathogens through its intracellular and extracellular killing as well as antimicrobial activity, and the degradation of extracellular matrix components, including elastin, collagens, fibroncetin and proteoglycans2.
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