During mRNA translation at ribosomes, specific amino-acyl-tRNA synthetases are required for the
covalently attachment between tRNAs and different amino acids.
Histidyl-tRNA synthetase (Jo-1) is specific for the amino acid histidine. Jo-1 is a frequent target of
autoantibodies in the human autoimmune disease polymyositis and/or dermatomyositis.
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