INTRODUCTION
During mRNA translation at ribosomes, specific amino-acyl-tRNA synthetases are required for the covalently attachment between tRNAs and different amino acids. Alanyl -tRNA synthetase (AARS, PL-12) is specific for the amino acid alanine. PL-12 is recognized by PL-12 autoantibodies which is present in a subset of patients with polymyositis and dermatomyositis.
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